Defending champion Chris Froome has pulled out of the Tour de France after crashing twice on stage five.
The Briton had resumed riding after his first fall in wet conditions, but withdrew after his second crash with around 66km of the stage to go.
The 29-year-old climbed into a Team Sky support car to leave the race.
The stage had yet to reach the first of several cobbled sections that team-mate Geraint Thomas had predicted would cause problems for the riders.
Froome had started the stage in seventh position, two seconds behind race leader Vincenzo Nibali.
He was cleared to resume racing following an X-ray after grazing his left hip and damaging a wrist when falling during the fourth stage on Tuesday.
Britain’s Mark Cavendish had already pulled out of the race after he dislocated his right shoulder and suffered ligament damage in a crash near the end of stage one, where Froome had finished in sixth place.
Froome had suffered cuts and abrasions to a shoulder after falling during the Criterium du Dauphine in mid-June.
He was chosen to lead Team Sky for this year’s race, while Sir Bradley Wiggins, who became the first British winner of the Tour in 2012, was omitted altogether.
The pair fell out during the 2012 Tour, when Froome appeared to disobey orders by pulling away from his team-mate during stage 11 before dropping back again.